Formulation And Evaluation Of Bioadhesive Buccal Tablets Of Felodipine.

Felodipine (FD) is a dihydropyridine used to treat blood pressure abnormality. FD is known as a secondgeneration calcium channel blocker, by hindering calcium uptake, this medication relaxes and expands the blood vessels, so the flow of blood can run more easily. The main objective of the study was to formulate and evaluate bioadhesive buccal tablets to avoid the first-pass metabolism in the liver and patient acceptance. Bioadhesive buccal tablets were prepared by direct compression method using bioadhesive polymers like carbopol, Hydroxyl propyl methyl cellulose K4M and Sodium Carboxy Methylcellulose in different combination with the drug. The physicochemical compatibility of drugs and polymers was studied by FT-IR spectroscopy. prepared tablets were evaluated for permeation study through sheep buccal mucosa, in vitro drug release, swelling index, moisture absorbance, surface pH, Among the prepared formulation containing F6 Shows maximum drug release 100.7 ± 0.09 in 8 hrs, the optimized formulation F6 showed surface pH 6.36 ± 0.219 and swelling index 90.2 % up to eight hours. The optimized formulation followed the Higuchi order diffusion mechanism. [ABSTRACT FROM AUTHOR]