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Role of FOLFIRINOX and chemoradiotherapy in locally advanced and borderline resectable pancreatic adenocarcinoma: update of the AGEO cohort.
- Source :
-
British Journal of Cancer . Jun2021, Vol. 124 Issue 12, p1941-1948. 8p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>FOLFIRINOX has shown promising results in locally advanced (LAPA) or borderline resectable (BRPA) pancreatic adenocarcinoma. We report here a cohort of patients treated with this regimen from the AGEO group.<bold>Methods: </bold>This is a retrospective multicentre study. We included all consecutive patients with non-pre-treated LAPA or BRPA treated with FOLFIRINOX.<bold>Results: </bold>We included 330 patients (57.9% male, 65.4% <65 years, 96.4% PS <2). Disease was classified as BRPA in 31.1% or LAPA in 68.9%. Objective response rate with FOLFIRINOX was 29.5% and stable disease 51%. Subsequent CRT was performed in 46.4% of patients and 23.9% had curative intent surgery. Resection rates were 42.1% for BRPA and 15.5% for LAPA. Main G3/4 toxicities were fatigue (15%), neutropenia (12%) and neuropathy (G2/3 35%). After a median follow-up of 26.7 months, median OS (mOS) and PFS were 21.4 and 12.4 months, respectively. For patients treated by FOLFIRINOX alone, or FOLFIRINOX followed by CRT, or FOLFIRINOX + /- CRT + surgery, mOS was 16.8 months, 21.8 months and not reached, respectively (p < 0.0001).<bold>Conclusions: </bold>FOLFIRINOX for LAPA and BRPA seems to be effective with a manageable toxicity profile. These promising results in "real-life" patients now have to be confirmed in a Phase 3 randomised trial. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of antineoplastic agents
*PANCREATIC tumors
*ADENOCARCINOMA
*DISEASE progression
*FOLINIC acid
*RESEARCH
*RESEARCH methodology
*RETROSPECTIVE studies
*MEDICAL cooperation
*EVALUATION research
*FLUOROURACIL
*TREATMENT effectiveness
*COMPARATIVE studies
*SURVIVAL analysis (Biometry)
*COMBINED modality therapy
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 124
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 150746772
- Full Text :
- https://doi.org/10.1038/s41416-021-01341-w