表观遗传学对牙周疾病及牙周细胞成骨和骨再生的作用机制.

BACKGROUND: Periodontal disease is a complex, heterogeneous and multi-factorial oral destructive disease caused mainly by bacteria, where the role of epigenetics cannot be ignored. OBJECTIVE: To summarize the epigenetic model of periodontal diseases that can measure periodontal susceptibility, and has diagnostic and therapeutic values for patients with periodontitis. METHODS: PubMed database was searched for relevant literatures published from 2005 to 2020 using the key words of “epigenetics; periodontal disease; inflammatory response; bone regeneration; diagnosis; periodontal tissue engineering.” After screening, 86 articles was finally reviewed. RESULTS AND CONCLUSION: Periodontal disease and epigenetics interact with each other. The discovery of the epigenetic regulation of oral pathogens on pathogen recognition receptors (such as Toll-like receptors) and pro-inflammatory/anti-inflammatory cytokines indicates that they play an important role in regulating the host immune response and are related to cellular osteogenesis and bone regeneration. In addition, the latest research in tissue engineering shows that epigenetics can also improve the regeneration of periodontal tissue. [ABSTRACT FROM AUTHOR]