窄谱中波紫外线联合卡泊三醇治疗银屑病症状转归及患者 治疗前后外周血细胞因子水平评价.

Objective To analyze the clinical efficacy of narrow-spectrum UVB in the treatment of psoriasis and the effect on peripheral blood cytokines. Methods 109 patients with psoriasis treated in the First Affiliated Hospital of Kunming Medical University from May 2018 to March 2020 were selected and randomly divided into experimental group(n = 55)and control group (n = 54). The control group was treated with capotriol ointment，and the experimental group was treated with narrow-spectrum UVB combined with capotriol ointment. The clinical efficacy and the changes of cytokines in peripheral blood of patients in the two groups were compared. Results The total effective rate of clinical treatment in the experimental group was higher than that of control group， and the difference was statistically significant (P < 0.05). After treatment, Th17, Treg and Th17/Treg in the experimental group were statistically significant in control group (P < 0.05). After treatment, TNF- radiation and il-10 in the experimental group were compared with those in the control group，and the difference was statistically significant (P < 0.05). Conclusion Narrow spectrum UVB treatment of psoriasis can improve the clinical outcomes，which may be related to the inhibition of serum TNF- beam and Th17 levels in patients with psoriasis， and the improvement of 1l-10 and Treg cell levels. UVB in narrow spectrum may play a role in improving Th17/Treg imbalance ratio and cytokine levels in patients with psoriasis, which has great potential in clinical practice. [ABSTRACT FROM AUTHOR]