伽玛刀治疗吗啡依赖猴双侧伏隔核后多巴胺 D3 受体变化的研究.

Objective To establish the experimental model of morphine dependent rhesus monkey and observe the changes of D3R expression in nucleus accumbens, hippocampus, cingulate gyrus and cortex of frontal lobe. Methods Four rhesus monkeys were divided into three groups: treatment group (Group A with two monkey), control group (Group B with one monkey) and normal group (Group C with one monkey). The model of morphine dependent monkey was established with imitated Seveers' method and treated by gamma-knife. The changes of D3R expression in nucleus accumbens, hippocampus，cingulate gyrus and cortex of frontal lobe of three groups were observed using immunohistochemistry. Results The D3R expression in Group B was higher than that in Group C ( < 0.001), and the expression density increased range from 254% to 499%. The D3R expression in Group A was lower than that in Group B (< 0.001), but higher than that in Group C. The D3R expression in the nucleus accumbens， hippocampus and cingulategyurs decreased significantly and the expression in nucleus accumbens approached normal after gamma-knife treatment. Conclusion The expression of D3R in the nucleus accumbens significantly decreased after gamma-knife treatment，suggesting D3R is effective to adjust the process of morphine addiction. [ABSTRACT FROM AUTHOR]