The role of vitamin D3 administration on IFN-γ, IL-1β expression and repair of colonic mucosa at mice models of ulcerative colitis.

Ulcerative colitis is an idiopathic inflammatory disorder affecting the small intestine and rectum mucosa. The main clinical manifestations are bloody diarrhea and abdominal pain. Vitamin D3 has a role in the immunological response and ulcerative colitis is an inflammatory disease closely related to decreased levels of vitamin D3. This study examined the effects of vitamin D3 on IFN-γ and IL-1β which play a role in colitis mechanism, and colonic mucosal repair in DSS-induced colitis mice models. This is an experimental study using a randomized post-test only control group design with 21 samples, divided into three groups. The results showed significant epithelial damage found in the positive control group (9.42 ± 2.16) compared to the negative control group (0.33 ± 0.26) and treatment group (6.29 ± 1.48) based on MCHI scores and there was a significant difference in IFN-γ and IL-1β expression levels of mice colon epithelial cells among the groups. [ABSTRACT FROM AUTHOR]