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The prevention of single bulb garlic extract on non-alcoholic fatty liver disease (NAFLD) in high fat mice (Mus musculus) model.
- Source :
-
AIP Conference Proceedings . 2020, Vol. 2353 Issue 1, p1-6. 6p. - Publication Year :
- 2020
-
Abstract
- Non-alcoholic fatty liver disease (NAFLD) occurs when triglycerides inside hepatocytes are swollen. A single bulb garlic extract containing allicin components, S-allyl-l-cysteine, Ajoene (E-Ajoene and Z-Ajoene) are thought to inhibit fat biosynthesis and reduce triglycerides in blood serum. This study aimed to analyze single bulb garlic extract in NAFLD due to a high-fat diet (HFD) in mice. Twenty male Balb/C mice were divided into five groups: normal, HFD, HFD + Single Bulb Garlic Extract (SBGE) 100 mg kg BW−1, HFD + SBGE 200 mg kg BW−1, and HFD + SBGE 400 mg kg BW−1. The administration of SBGE orally altogether with HFD for 30 days. On the last day of treatment, the mice were sacrificed. The liver was collected to make a micro-anatomic slide and stained by Hematoxylin Eosin. Liver microanatomy slides were observed under a light microscope and scoring to count fatty liver cells. The results of this study indicated that administration of SBGE affected the average liver weight (p < 0.05). Treating SBGE with dose of 100 mg kg BW−1, 200 mg kg BW−1, and 400 mg kg BW−1 decreased hepatic steatosis (p < 0.05). SBGE could prevent non-alcoholic fatty liver disease in mice fed with HFD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NON-alcoholic fatty liver disease
*MICE
*GARLIC
*FATTY liver
*LIVER cells
Subjects
Details
- Language :
- English
- ISSN :
- 0094243X
- Volume :
- 2353
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- AIP Conference Proceedings
- Publication Type :
- Conference
- Accession number :
- 150500703
- Full Text :
- https://doi.org/10.1063/5.0052672