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Disulfide bond based cascade reduction-responsive Pt(IV) nanoassemblies for improved anti-tumor efficiency and biosafety.
- Source :
-
Colloids & Surfaces B: Biointerfaces . Jul2021, Vol. 203, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- [Display omitted] • Cascade GSH-responsive drug delivery platform for Pt(IV) prodrug. • Alleviated systemic toxicity and ensured biosafety. • High drug loading capacity and colloid stability. The platinum-based drugs prevail in the therapy of malignant tumors treatment. However, their clinical outcomes have been heavily restricted by severe systemic toxicities. To ensure biosafety and efficiency, herein, we constructed a disulfide bond inserted Pt(IV) self-assembled nanoplatform that is selectively activated by rich glutathione (GSH) in tumor site. Disulfide bond was introduced into the conjugates of oxaliplatin (IV) and oleic acid (OA) which conferred cascade reduction-responsiveness to nanoassemblies. Disulfide bond cleavage and reduction of Pt(IV) center occur sequentially as a cascade process. In comparison to oxaliplatin solution, Pt(IV) nanoparticles (NPs) achieved prolonged blood circulation and higher maximum tolerated doses. Furthermore, Oxa(IV)-SS-OA prodrug NPs exhibited potent anti-tumor efficiency against 4T1 cells and low toxicities in other normal tissues, which offers a promising nano-platform for potential clinical application. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOSAFETY
*TREATMENT effectiveness
*OLEIC acid
*SCISSION (Chemistry)
*GLUTATHIONE
Subjects
Details
- Language :
- English
- ISSN :
- 09277765
- Volume :
- 203
- Database :
- Academic Search Index
- Journal :
- Colloids & Surfaces B: Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 150469795
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2021.111766