老年2型糖尿病患者血清BGP、ghrelin、YKL-40水平与胰岛素抵抗及认知功能损害的关系研究.

Objective: To study the relationship between serum osteocalcin (BGP), growth hormone releasing peptide (ghrelin) and human cartilage glycoprotein-39 (YKL-40) levels and insulin resistance and cognitive impairment in elderly patients with type 2 diabetes mellitus (T2DM). Methods: 100 elderly patients with T2DM who were admitted to our hospital from January 2018 to December 2019 were seelected as the lesion group. Another 100 healthy elderly volunteers who underwent physical examination in our hospital at the same time were selected as the control group. The levels of BGP, ghrelin and YKL-40, blood glucose, blood lipid and insulin resistance, cognitive impairent and simple mental state examination scale (MMSE) score were compared between the two groups, and correlation analysis was performed. Results: The serum BGP and ghrelin level of the lesion group were lower than those of the control group, while the levels of YKL-40 was higher than that of the control group (P<0.05). Fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c) and insulin resistance index (HOMA-IR) levels in the lesion group were higher than those in the control group, while fasting insulin (fins) levels were lower than those in the control group (P<0.05). There was no significant difference between the pathological group and the control group except for the scores of language and delayed memory (P>0.05), Other MMSE scores were lower than those of the control group (P<0.05). According to Pearson correlation analysis, serum BGP, ghrelin, FPG, HbA1c and HOMA-IR were negatively correlated with fins and MMSE scores (P<0.05), while serum YKL-40 was positively correlated with FPG, HbA1c and HOMA-IR, and negatively correlated with fins and MMSE scores (P<0.05). Conclusions: Serum BGP and ghrelin are significantly lower in elderly T2DM patients, while serum YKL-40 is significantly higher, and the above serological indexes are closely related to insulin resistance and cognitive impairment. [ABSTRACT FROM AUTHOR]