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Quantized sampled-data static output feedback control of the glucose–insulin system.
- Source :
-
Control Engineering Practice . Jul2021, Vol. 112, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- In this paper, the plasma glucose regulation problem for type 2 diabetic patients is studied. A nonlinear time-delay model of the glucose–insulin regulatory system is exploited to design a quantized sampled-data static output feedback control, using only glucose measurements. It is shown that the proposed control law achieves semiglobal practical stability of the related quantized sampled-data closed-loop glucose–insulin system with arbitrary small steady-state tracking error. The controller involves past values of the glucose, which may not be available in the buffer, for instance because of non-uniform sampling. Such a drawback is overcome by means of spline interpolation. Furthermore, quantization in both input and output channels are taken into account. A pre-clinical validation, concerning the performances of the proposed glucose regulator, is carried out by means of a well-known simulator of diabetic patients, broadly accepted for testing insulin infusion therapies. The simulation results pave the way for further clinical evaluation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09670661
- Volume :
- 112
- Database :
- Academic Search Index
- Journal :
- Control Engineering Practice
- Publication Type :
- Academic Journal
- Accession number :
- 150412350
- Full Text :
- https://doi.org/10.1016/j.conengprac.2021.104828