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First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population.
First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population.
- Source :
-
American Journal of Clinical Pathology . Jun2021, Vol. 155 Issue 6, p776-780. 5p. - Publication Year :
- 2021
-
Abstract
- <bold>Objectives: </bold>Thyroid dysfunction in pregnancy is associated with increased risk of adverse outcomes to mother and child. Trimester-specific reference intervals for thyroid function tests are not routinely provided by clinical laboratories. In this study, we present first- and second-trimester-specific reference intervals in a US population for thyroid-stimulating hormone (TSH), free thyroxine (FT4), total thyroxine (T4), and total triiodothyronine (T3) measured on Roche analyzers.<bold>Methods: </bold>We used patient samples from first- and second-trimester prenatal screening. Samples were limited to singleton pregnancies and negative screening results for thyroid peroxidase and thyroglobulin antibodies. Analytes (TSH, FT4, T4, and T3) were measured on a Roche Modular e170 then verified on a Roche cobas e801.<bold>Results: </bold>The reference intervals established on the e170 and verified on the e801 for the first trimester were 0.16 to 2.82 mIU/L for TSH, 12.0 to 18.5 pmol/L for FT4, 62.8 to 177.9 nmol/L for T4, and 1.5 to 3.4 nmol/L for T3. The reference intervals for the second trimester were 0.40 to 3.62 mIU/L for TSH, 10.2 to 16.6 pmol/L for FT4, 66.6 to 176.0 nmol/L for T4, and 1.56 to 3.6 nmol/L for T3.<bold>Conclusions: </bold>This is the first report of trimester-specific reference intervals for thyroid function tests on Roche analyzers in the United States, and it is consistent with worldwide reports. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00029173
- Volume :
- 155
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Journal of Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 150407027
- Full Text :
- https://doi.org/10.1093/ajcp/aqaa165