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First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population.

First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population.

Authors :
Bunch, Dustin R
Firmender, Kyle
Harb, Roa
El-Khoury, Joe M
Source :
American Journal of Clinical Pathology. Jun2021, Vol. 155 Issue 6, p776-780. 5p.
Publication Year :
2021

Abstract

<bold>Objectives: </bold>Thyroid dysfunction in pregnancy is associated with increased risk of adverse outcomes to mother and child. Trimester-specific reference intervals for thyroid function tests are not routinely provided by clinical laboratories. In this study, we present first- and second-trimester-specific reference intervals in a US population for thyroid-stimulating hormone (TSH), free thyroxine (FT4), total thyroxine (T4), and total triiodothyronine (T3) measured on Roche analyzers.<bold>Methods: </bold>We used patient samples from first- and second-trimester prenatal screening. Samples were limited to singleton pregnancies and negative screening results for thyroid peroxidase and thyroglobulin antibodies. Analytes (TSH, FT4, T4, and T3) were measured on a Roche Modular e170 then verified on a Roche cobas e801.<bold>Results: </bold>The reference intervals established on the e170 and verified on the e801 for the first trimester were 0.16 to 2.82 mIU/L for TSH, 12.0 to 18.5 pmol/L for FT4, 62.8 to 177.9 nmol/L for T4, and 1.5 to 3.4 nmol/L for T3. The reference intervals for the second trimester were 0.40 to 3.62 mIU/L for TSH, 10.2 to 16.6 pmol/L for FT4, 66.6 to 176.0 nmol/L for T4, and 1.56 to 3.6 nmol/L for T3.<bold>Conclusions: </bold>This is the first report of trimester-specific reference intervals for thyroid function tests on Roche analyzers in the United States, and it is consistent with worldwide reports. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00029173
Volume :
155
Issue :
6
Database :
Academic Search Index
Journal :
American Journal of Clinical Pathology
Publication Type :
Academic Journal
Accession number :
150407027
Full Text :
https://doi.org/10.1093/ajcp/aqaa165