Monoclonal Gammopathy of Renal Significance.

The article focuses on monoclonal gammopathy of renal significance, a term that describes any B-cell or plasma-cell clonal disorder that does not fulfill the criteria for cancer yet produces a nephrotoxic monoclonal immunoglobulin that leads to kidney injury or disease. Topics include criiteria for treatment of chronic lymphocytic leukemia are lymphocytosis; and patients who neither meet the clonal burden criterion nor have end-organ damage receive a diagnosis of monoclonal gammopathy.