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The Different Facets of Triclocarban: A Review.

Authors :
Iacopetta, Domenico
Catalano, Alessia
Ceramella, Jessica
Saturnino, Carmela
Salvagno, Lara
Ielo, Ileana
Drommi, Dario
Scali, Elisabetta
Plutino, Maria Rosaria
Rosace, Giuseppe
Sinicropi, Maria Stefania
Ghadiri, M. Reza
Source :
Molecules. May2021, Vol. 26 Issue 9, p2811-2811. 1p.
Publication Year :
2021

Abstract

In the late 1930s and early 1940s, it was discovered that the substitution on aromatic rings of hydrogen atoms with chlorine yielded a novel chemistry of antimicrobials. However, within a few years, many of these compounds and formulations showed adverse effects, including human toxicity, ecotoxicity, and unwanted environmental persistence and bioaccumulation, quickly leading to regulatory bans and phase-outs. Among these, the triclocarban, a polychlorinated aromatic antimicrobial agent, was employed as a major ingredient of toys, clothing, food packaging materials, food industry floors, medical supplies, and especially of personal care products, such as soaps, toothpaste, and shampoo. Triclocarban has been widely used for over 50 years, but only recently some concerns were raised about its endocrine disruptive properties. In September 2016, the U.S. Food and Drug Administration banned its use in over-the-counter hand and body washes because of its toxicity. The withdrawal of triclocarban has prompted the efforts to search for new antimicrobial compounds and several analogues of triclocarban have also been studied. In this review, an examination of different facets of triclocarban and its analogues will be analyzed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14203049
Volume :
26
Issue :
9
Database :
Academic Search Index
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
150373406
Full Text :
https://doi.org/10.3390/molecules26092811