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Metabolic checkpoint of ferroptosis resistance.
- Source :
-
Molecular & Cellular Oncology . 2021, Vol. 8 Issue 3, p1-3. 3p. - Publication Year :
- 2021
-
Abstract
- The metabolic checkpoint of ferroptosis remains obscure. We find that glucose favors system xc− inhibitor-induced ferroptosis by activating pyruvate oxidation, thereby promoting fatty acid synthesis and subsequent lipid peroxidation. In contrast, the upregulation of pyruvate dehydrogenase kinase 4 (PDK4) switches into a ferroptosis-resistant state in pancreatic cancer cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 8
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 150335638
- Full Text :
- https://doi.org/10.1080/23723556.2021.1901558