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Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making.
- Source :
-
Behavioural Brain Research . Jul2021, Vol. 409, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- To survive in a complex environment, individuals form associations between environmental stimuli and rewards to organize and optimize reward seeking behaviors. The basolateral amygdala (BLA) uses these learned associations to inform decision-making processes. In this review, we describe functional projections between BLA and its cortical and striatal targets that promote learning and motivational processes central to decision-making. Specifically, we compare and contrast divergent projections from the BLA to the orbitofrontal (OFC) and to the nucleus accumbens (NAc) and examine the roles of these pathways in associative learning, value-guided decision-making, choice behaviors, as well as cue and context-driven drug seeking. Finally, we consider how these projections are involved in disorders of motivation, with a focus on Substance Use Disorder. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01664328
- Volume :
- 409
- Database :
- Academic Search Index
- Journal :
- Behavioural Brain Research
- Publication Type :
- Academic Journal
- Accession number :
- 150317230
- Full Text :
- https://doi.org/10.1016/j.bbr.2021.113306