Association between human papillomavirus infection and sperm quality: A systematic review and a meta‐analysis.

Human papillomavirus (HPV) has a high incidence rate in both males and females. HPV infection in women has been shown to affect fertility and lead to foetal death and pregnancy loss. However, research on HPV infection in men is limited. The aim of this study was to study the effect of HPV infection in semen on sperm quality and present the findings of previous studies through a meta‐analysis. Databases including PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library, WanFang data and China National Knowledge Infrastructure were searched for relevant studies. A systematic review and meta‐analysis were performed, and 17 studies were included for analyses based on a set criterion. Meta‐analyses indicated that HPV infection in semen significantly reduced sperm concentration (SMD = −0.12, 95% CI: −0.21 to −0.03, p =.009), sperm motility (SMD = −0.55, 95% CI: −0.780 to −0.33, p =.000), sperm viability (SMD = −0.55, 95% CI: −0.780 to −0.33, p =.000) and sperm morphology (SMD = −0.34, 95% CI: −0.61 to −0.07, p =.015). The high‐risk HPV (HrHPV) infection could significantly reduce sperm count (SMD = −0.65, 95% CI: −1.11 to −0.18, p =.007) compared with high‐risk HPV (LrHPV) infection. In conclusion, HPV infection in semen significantly reduced sperm quality, and the HrHPV infection could significantly reduce sperm count compared with LrHPV. [ABSTRACT FROM AUTHOR]