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A new degree of complexi(n)ty in the regulation of GLUT4 trafficking.
- Source :
-
Biochemical Journal . Apr2021, Vol. 478 Issue 7, p1315-1319. 5p. - Publication Year :
- 2021
-
Abstract
- Loss of the insulin-stimulated glucose uptake in muscle is a crucial event participating in the defect of whole-body metabolism in type 2 diabetes. Therefore, identification by Pavarotti et al. (Biochem. J (2021) 478 (2): 407-422) of complexin-2 as an important contributor to glucose transporter 4 (GLUT4) translocation to muscle cell plasma membrane upon insulin stimulation is essential. The present commentary discusses the biological importance of the findings and proposes future challenges and opportunities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02646021
- Volume :
- 478
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Biochemical Journal
- Publication Type :
- Academic Journal
- Accession number :
- 150267415
- Full Text :
- https://doi.org/10.1042/BCJ20210008