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Cardiac hypertrophic risk markers of left ventricle and left atrium in chronic heart failure due to aortic and mitral valve disease.
- Source :
-
Acta Radiologica . May2021, Vol. 62 Issue 5, p603-609. 7p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Chronic valvular heart disease leads to systolic dysfunction and left atrial enlargement that ultimately results in heart failure.<bold>Purpose: </bold>To investigate prognostic importance of Echocardiography and plasma natriuretic peptide levels that increase as a compensatory response and can be used as predictive markers for cardiac hypertrophy.<bold>Material and Methods: </bold>The patients were divided into three groups: 51 with left ventricle hypertrophy due to aortic valve disease; 126 with left atrial enlargement due to mitral valve dysfunction; and 76 with both conditions. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) plasma levels were measured in all three respective groups showing dilated cardiomyopathy.<bold>Results: </bold>The mean left ventricular end-diastolic dimension at 64.3 ± 1.6 mm (P < 0.00) and left atrial dimension at 58.3 ± 3.7 mm (P < 0.00) were significantly high. However, patients with both conditions showed significantly high values for left ventricular end-diastolic dimension (63.3 ± 3 mm, P < 0.00) and left atrial dimension (54.9 ± 4 mm, P < 0.00) when compared with controls. A significant positive correlation was found between plasma natriuretic peptides levels and dilated cardiomyopathy. The mean values of ANP were 173 ± 46.6 pg/mL (P < 0.00), 140.4 ± 42.4 pg/mL (P < 0.00), and 295.1 ± 67.5 pg/mL (P < 0.00), significantly high in all three respective disease groups. The levels of BNP were also significantly high at 189 ± 44.5 pg/mL (P < 0.00), 166.6 ± 36.6 pg/mL (P < 0.00), and 323 ± 69.1 pg/mL (P < 0.00) in the disease groups with left ventricular hypertrophy, left atrial enlargement, and the disease group showing both characteristics, respectively.<bold>Conclusion: </bold>Significant positive associations were found between left ventricle hypertrophy and left atrial enlargement with ANP and BNP. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AORTIC valve diseases
*LEFT heart atrium
*HEART failure
*LEFT ventricular hypertrophy
*HEART valve diseases
*CARDIAC hypertrophy
*MITRAL valve
*ECHOCARDIOGRAPHY
*PREDICTIVE tests
*CHRONIC diseases
*PROGNOSIS
*RISK assessment
*HEART ventricles
*ATRIAL natriuretic peptides
*HEART atrium
*AORTIC valve
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 02841851
- Volume :
- 62
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Acta Radiologica
- Publication Type :
- Academic Journal
- Accession number :
- 150228546
- Full Text :
- https://doi.org/10.1177/0284185120933530