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High Frequency of SARS-CoV-2 RNAemia and Association With Severe Disease.
- Source :
-
Clinical Infectious Diseases . 5/1/2021, Vol. 72 Issue 9, pe291-e295. 5p. - Publication Year :
- 2021
-
Abstract
- Background Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in blood, also known as RNAemia, has been reported, but its prognostic implications are poorly understood. This study aimed to determine the frequency of SARS-CoV-2 RNA in plasma and its association with coronavirus disease 2019 (COVID-19) clinical severity. Methods An analytical cross-sectional study was performed in a single-center tertiary care institution and included consecutive inpatients and outpatients with confirmed COVID-19. The prevalence of SARS CoV-2 RNAemia and the strength of its association with clinical severity variables were examined and included intensive care unit (ICU) admission, invasive mechanical ventilation, and 30-day all-cause mortality. Results Paired nasopharyngeal and plasma samples were included from 85 patients. The median age was 55 years, and individuals with RNAemia were older than those with undetectable SARS-CoV-2 RNA in plasma (63 vs 50 years; P =.04). Comorbidities were frequent including obesity (37.6%), hypertension (30.6%), and diabetes mellitus (22.4%). RNAemia was detected in 28/85 (32.9%) of patients, including 22/28 (78.6%) who required hospitalization. In models adjusted for age, RNAemia was detected more frequently in individuals who developed severe disease including ICU admission (32.1 vs 14.0%; P =.04) and invasive mechanical ventilation (21.4% vs 3.5%; P =.02). All 4 deaths occurred in individuals with detectable RNAemia. An additional 121 plasma samples from 28 individuals with RNAemia were assessed longitudinally, and RNA was detected for a maximum duration of 10 days. Conclusions This study demonstrated a high proportion of SARS-CoV-2 RNAemia, and an association between RNAemia and clinical severity suggesting the potential utility of plasma viral testing as a prognostic indicator for COVID-19. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTENSIVE care units
*OBESITY
*HYPERTENSION
*SARS-CoV-2
*COVID-19
*BLOOD plasma
*CROSS-sectional method
*OPERATIVE surgery
*RNA
*TERTIARY care
*PATIENTS
*DIABETES
*SEVERITY of illness index
*HOSPITAL admission & discharge
*ARTIFICIAL respiration
*VIREMIA
*DISEASE prevalence
*DESCRIPTIVE statistics
*HOSPITAL care
*COMORBIDITY
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 72
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 150175678
- Full Text :
- https://doi.org/10.1093/cid/ciaa1054