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Long‐Term Safety and Efficacy of Anifrolumab in Adults With Systemic Lupus Erythematosus: Results of a Phase II Open‐Label Extension Study.
- Source :
-
Arthritis & Rheumatology . May2021, Vol. 73 Issue 5, p816-825. 10p. - Publication Year :
- 2021
-
Abstract
- Objective: To investigate long‐term safety and tolerability of anifrolumab, a human monoclonal antibody to the type I interferon (IFN) receptor subunit 1, in patients with moderate‐to‐severe systemic lupus erythematosus (SLE). Methods: This 3‐year, multinational, open‐label extension study included adult patients who completed treatment (48 weeks of anifrolumab or placebo; 12‐week follow‐up) in the MUSE phase IIb randomized controlled trial (RCT). Patients initially received 1,000 mg of anifrolumab intravenously every 4 weeks, which was reduced to 300 mg every 4 weeks based on the benefit/risk profile established in the MUSE trial. Adverse events (AEs) were assessed monthly. Exploratory end points included the SLE Disease Activity Index 2000 (SLEDAI‐2K), Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), pharmacodynamics, and health‐related quality of life (HRQoL). Results: Of the 246 patients who completed the RCT, 218 (88.6%) enrolled in the open‐label extension study, of which 139 (63.8%) completed 3 years of treatment. Approximately 69.7% of patients reported ≥1 AE during the first year of open‐label extension treatment. Frequency and patterns of serious AEs and AEs of special interest over 3 years were consistent with those reported for 1 year of treatment in the RCT. Few patients (6.9%) discontinued treatment due to AEs. No new safety signals were identified. Improvement in the SLEDAI‐2K was sustained over 3 years. SDI and Short Form 36 health survey scores remained stable. Neutralization of type I IFN gene signatures was maintained in the IFN‐high population, and C3, C4, and anti–double‐stranded DNA showed trends toward sustained improvement. Conclusion: Long‐term anifrolumab treatment demonstrates an acceptable safety profile with sustained improvement in SLE disease activity, HRQoL, and serologic measures. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of interferons
*THERAPEUTIC use of monoclonal antibodies
*DRUG efficacy
*DRUG tolerance
*SERODIAGNOSIS
*CELL receptors
*IMMUNOSUPPRESSION
*MONOCLONAL antibodies
*SEVERITY of illness index
*RANDOMIZED controlled trials
*SYMPTOMS
*DESCRIPTIVE statistics
*SYSTEMIC lupus erythematosus
*IMMUNOSUPPRESSIVE agents
*DRUG side effects
*TERMINATION of treatment
*PATIENT safety
*EVALUATION
*ADULTS
Subjects
Details
- Language :
- English
- ISSN :
- 23265191
- Volume :
- 73
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Arthritis & Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 150065527
- Full Text :
- https://doi.org/10.1002/art.41598