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MiR-210-5p regulates STAT3 activation by targeting STAT5A in the differentiation of dermal fibroblasts.
- Source :
-
3 Biotech . 4/29/2021, Vol. 11 Issue 5, p1-11. 11p. - Publication Year :
- 2021
-
Abstract
- Elucidating the molecular mechanism of the microRNAs in skin fibrosis is critical for identifying a novel therapeutic strategy for hypertrophic scar (HS). In this study, it was shown that miR-210-5p is induced by TGFβ, and that overexpression of miR-210-5p promoted the differentiation of human dermal fibroblasts (HDFs) into myofibroblasts. STAT5A is required for TGFβ-induced STAT3 activity. Here, we show that miR-210-5p attenuated TGFβ-induced STAT3 signaling pathway by suppressing the expression of STAT5A. Taken together, the present study suggests that TGFβ-induced miR-210-5p reduced STAT5A expression, leading to aberrant activation of STAT3, and facilitate skin fibrosis in HDFs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FIBROBLASTS
*HYPERTROPHIC scars
*MYOFIBROBLASTS
*MICRORNA
*FIBROSIS
Subjects
Details
- Language :
- English
- ISSN :
- 2190572X
- Volume :
- 11
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- 3 Biotech
- Publication Type :
- Academic Journal
- Accession number :
- 150063561
- Full Text :
- https://doi.org/10.1007/s13205-021-02777-w