Metachromatic leukodystrophy with late adult-onset: diagnostic clues and differences from other genetic leukoencephalopathies with dementia.

In addition, common non-inherited forms of cerebral small vessel diseases [[6]], which can be associated with leukoencephalopathy and dementia, should be excluded based on lack of vascular risk factors and stroke events, and brain MRI features, including white matter lesion topography and absence of macro- and micro-hemorrhages. No microhemorrhage was present on T2*-weighted sequences (not shown) MLD is an autosomal recessive (AR) lysosomal disorder with typical onset in the first years of life. The original online version of this article was revised: The subtitle of the lower part of the table 1 is "Genetic leukoencephalopathies with dementia as predominant features" and not "Genetic leukoencephalopathies with dementia as prominent features". [Extracted from the article]