Dermatitis fotoalérgica grave asociada con alopurinol.

BACKGROUND: Secondary skin reactions to medications are estimated in 3 to 7% in hospital emergency services. The term photosensitivity in its broadest sense refers to any alteration induced by the absorption of non-ionizing energy. CLINICAL CASE: A 50-year-old male patient with hyperuricemia of one month of diagnosis under treatment with allopurinol 300 mg/day, which began his dermatosis one month after sun exposure for working hours of approximately 6-8 hours, with vesicles and blisters on his face, subsequent spread to the upper extremities and trunk, associated with itching of intensity 9/10 and poor general condition. Patient warranted hospitalization due to acute kidney injury and severity of his dermatosis. Management was started with general skin care, intravenous hydrocortisone at 100 mg every 6 hours, drying promotions with a colloid bath and due to antibiotic ceftriaxone 1 g/day meliceric crusts; in addition to fluid therapy by internal medicine. Patient had favorable response. CONCLUSIONS: Photosensitizing drugs can be administered topically and/or systemically and cause a phototoxic or photoallergic reaction in some cases with high morbidity and mortality. [ABSTRACT FROM AUTHOR]