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Heparinem indukovaná trombocytopenie.
- Source :
-
Transfusiology & Haematology Today / Transfuze a Hematologie Dnes . 2021, Vol. 27 Issue 1, p9-15. 7p. - Publication Year :
- 2021
-
Abstract
- Heparin induced thrombocytopenia (HIT) represents a very serious complication of heparin therapy associated with high morbidity and/or mortality. HIT is caused by generation of antibodies against macromolecular complexes of heparin/platelet factor 4 resulting in activation of platelets, monocytes, endothelium and neutrophils with subsequent high thrombin generation and induction of a hypercoagulable state. Therapy with heparins must be interrupted and alternative non-heparin antithrombotics must be introduced. The dia-gnosis of HIT is based on clinical findings namely the so called 4T score and laboratory tests. Immunological tests have a high negative predictive value in excluding HIT. In positive cases, the dia-gnosis must be confirmed by functional tests. Novel developments in the therapy of HIT include the introduction of the new direct oral anticoagulants. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Czech
- ISSN :
- 12135763
- Volume :
- 27
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Transfusiology & Haematology Today / Transfuze a Hematologie Dnes
- Publication Type :
- Academic Journal
- Accession number :
- 149662955
- Full Text :
- https://doi.org/10.48095/cctahd20219