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Hippo pathway: Regulation, deregulation and potential therapeutic targets in cancer.
- Source :
-
Cancer Letters . Jun2021, Vol. 507, p112-123. 12p. - Publication Year :
- 2021
-
Abstract
- Hippo pathway is a master regulator of development, cell proliferation, stem cell function, tissue regeneration, homeostasis, and organ size control. Hippo pathway relays signals from different extracellular and intracellular events to regulate cell behavior and functions. Hippo pathway is conserved from Protista to eukaryotes. Deregulation of the Hippo pathway is associated with numerous cancers. Alteration of the Hippo pathway results in cell invasion, migration, disease progression, and therapy resistance in cancers. However, the function of the various components of the mammalian Hippo pathway is yet to be elucidated in detail especially concerning tumor biology. In the present review, we focused on the Hippo pathway in different model organisms, its regulation and deregulation, and possible therapeutic targets for cancer treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL physiology
*CELL proliferation
*DISEASE progression
*STEM cells
*PROTEIN metabolism
*THERAPEUTIC use of antineoplastic agents
*PROTEINS
*RESEARCH
*EXOSOMES
*ANIMAL experimentation
*RESEARCH methodology
*SIGNAL peptides
*MEDICAL cooperation
*EVALUATION research
*CELLULAR signal transduction
*COMPARATIVE studies
*TRANSFERASES
*GENES
*DRUG therapy
*TUMORS
*DRUG resistance in cancer cells
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 507
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 149589479
- Full Text :
- https://doi.org/10.1016/j.canlet.2021.03.006