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Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule
- Source :
-
Comparative Biochemistry & Physiology Part C: Toxicology & Pharmacology . Jul2004, Vol. 138 Issue 3, p245-249. 5p. - Publication Year :
- 2004
-
Abstract
- We used zebrafish to screen and identify small molecules that affect the process of vertebrate hematopoietic development. Zebrafish embryos were exposed to a library of 5000 synthetic compounds and screened for defects in primitive erythropoiesis. Here, we present the characterization of hemolytic anemia induced in zebrafish by the small molecule 5115318 (3-[5-methyl-furan 2-yl]-propionic acid N′-phenyl-hydrazide). This compound is capable of generating hemoglobin aggregates and Heinz bodies in red cells in vivo only. The induced anemia is reversible and treated fish recover in about 4 days. This study shows the feasibility of using zebrafish to screen for small molecules that can modulate the specific process of erythropoiesis. [Copyright &y& Elsevier]
- Subjects :
- *ZEBRA danio
*EMBRYOS
*ERYTHROPOIESIS
*HEMOLYTIC anemia
*ANEMIA
Subjects
Details
- Language :
- English
- ISSN :
- 15320456
- Volume :
- 138
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Comparative Biochemistry & Physiology Part C: Toxicology & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 14958021
- Full Text :
- https://doi.org/10.1016/j.cca.2004.05.003