Rh(III)‐Catalyzed C−H Activation/Annulation of Aryl Hydroxamates with CF3‐Containing α‐Propargyl α‐Amino Acid Derivatives.

A series of new orthogonally protected α‐CF3‐substituted α‐amino carboxylates, and α‐amino phosphonates decorated with pharmacophore isoquinolone core has been elaborated through the Rh(III)‐catalyzed C−H activation/annulation of aryl hydroxamates with propargyl‐containing α‐amino acid derivatives and their phosphorus analogues. [ABSTRACT FROM AUTHOR]