Back to Search
Start Over
Phoenix dactylifera polyphenols improve plasma lipid profile in hyperlipidemic rats and oxidative stress on HepG2 cells.
- Source :
-
Journal of Herbs, Spices & Medicinal Plants . 2021, Vol. 27 Issue 2, p161-176. 16p. - Publication Year :
- 2021
-
Abstract
- The anti-hyperlipidemic potential of Algerian date palm fruits of three varieties [Deglet nour (DN), Ghars (GH), Degla baida (DB)] and its influence on oxidative stress were explored in rat models using human hepatocellular carcinoma cells (HepG2). Phenolic profile and total phenolic content of the extracts revealed in vitro antioxidant potential, which was confirmed using HepG2 cells. Reduction of TBARS level and increase in NO levels were observed in cell medium. In vivo assays showed that administration of date extracts influenced the hypolipidemic effect in rats by decreasing total cholesterol (−51% for DB, −31% for GH and −30% for DN), triacylglycerol (−61% for DN, −54% for DB and −32% for GH) and LDL-Cholesterol, while increasing HDL-Cholesterol level, indicating strong cardioprotective properties of date fruit. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DRUG therapy for hyperlipidemia
*IN vitro studies
*TRIGLYCERIDES
*STATISTICS
*POLYPHENOLS
*IN vivo studies
*HIGH performance liquid chromatography
*ANALYSIS of variance
*ANIMAL experimentation
*LOW density lipoproteins
*ANTIOXIDANTS
*OXIDATIVE stress
*RATS
*DESCRIPTIVE statistics
*CELL lines
*HIGH density lipoproteins
*DATA analysis
*STATISTICAL correlation
*DATA analysis software
*LIPIDS
*CHOLESTEROL
*LIPID peroxidation (Biology)
THERAPEUTIC use of plant extracts
Subjects
Details
- Language :
- English
- ISSN :
- 10496475
- Volume :
- 27
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Herbs, Spices & Medicinal Plants
- Publication Type :
- Academic Journal
- Accession number :
- 149413578
- Full Text :
- https://doi.org/10.1080/10496475.2021.1891175