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The Saccharomyces cerevisiae ABC subfamily D transporter Pxa1/Pxa2p co‐imports CoASH into the peroxisome.
- Source :
-
FEBS Letters . Mar2021, Vol. 595 Issue 6, p763-772. 10p. - Publication Year :
- 2021
-
Abstract
- ATP‐binding cassette (ABC) subfamily D transporters are important for the uptake of fatty acids and other beta‐oxidation substrates into peroxisomes. Genetic and biochemical evidence indicates that the transporters accept fatty acyl‐coenzyme A that is cleaved during the transport cycle and then re‐esterified in the peroxisomal lumen. However, it is not known whether free coenzyme A (CoA) is released inside or outside the peroxisome. Here we have used Saccharomyces cerevisiae and isolated peroxisomes to demonstrate that free CoA is released in the peroxisomal lumen. Thus, ABC subfamily D transporter provide an import pathway for free CoA that controls peroxisomal CoA homeostasis and tunes metabolism according to the cell's demands. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SACCHAROMYCES cerevisiae
*PEROXISOMES
*COENZYME A
*FATTY acids
*CELL metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 595
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 149411498
- Full Text :
- https://doi.org/10.1002/1873-3468.13974