Mecanismos moleculares do envelhecimento: revisão da literatura.

Aging is a natural process characterized by a progressive decline in the physiological integrity and regenerative capacity of the body. In pathological aging, decline is accelerated and is often associated with a systemic pro-inflammatory status. Reactive species of oxygen and other free radicals are produced naturally in metabolism and during inflammation, but in excess they cause oxidative stress and tissue damage. With aging, the accumulation of oxidative changes alters the structure and function of biomolecules and cellular components such as membranes and organelles, making the organism globally more susceptible to stressors and pathogens. This review will focus on the contribution of oxidative stress to the different molecular mechanisms of aging. Aging is the main risk factor for the development of chronic--degenerative diseases. Therefore, the understanding of its molecular mechanisms will contribute to the development of new therapeutic strategies aimed at increasing the quality of life in aging. [ABSTRACT FROM AUTHOR]