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Hispidulin alleviates 2,4-dinitrochlorobenzene and house dust mite extract-induced atopic dermatitis-like skin inflammation.
- Source :
-
Biomedicine & Pharmacotherapy . May2021, Vol. 137, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
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Abstract
- Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects 10–20% of the world's population. Therefore, the discovery of drugs for the treatment of AD is important for human health. Hispidulin (HPD; also known as scutellarein 6-methyl ether or dinatin) is a natural flavone that exerts anti-inflammatory effects. In the present study, the effectiveness of HPD on AD-like skin inflammation was investigated. We used a mouse AD model through repeated exposure of mice to 2,4-dinitrochlorobenzene and house dust mite extract (Dermatophagoides farinae extract, DFE) to the ears. In addition, tumor necrosis factor-α and interferon-γ-activated keratinocytes (HaCaT cells) were used to investigate the underlying mechanism of HPD action. Oral administration of HPD alleviated AD-like skin inflammations: it reduced ear thickness; serum immunoglobulin (Ig)E, DFE-specific IgE, and IgG2a levels; and inflammatory cell infiltration. HPD reduced the expression of pro-inflammatory cytokines and chemokines through inhibition of signal transducer and activator of transcription 1 nuclear factor-κB in HaCaT cells. Taken together, these results suggest that HPD could be a potential drug candidate for the treatment of AD. [Display omitted] • Hispidulin (HPD) alleviated atopic dermatitis (AD)-like skin inflammation. • HPD decreased the infiltration of eosinophils and mast cells, and Th1/Th2 response. • HPD blocked the NF-κB and STAT1 signal pathways in keratinocytes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07533322
- Volume :
- 137
- Database :
- Academic Search Index
- Journal :
- Biomedicine & Pharmacotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 149367585
- Full Text :
- https://doi.org/10.1016/j.biopha.2021.111359