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α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms.
- Source :
-
Science Advances . 3/10/2021, Vol. 7 Issue 11, p1-12. 12p. - Publication Year :
- 2021
-
Abstract
- The article presents a study which identified a cell-autonomous selective Kv4 channelopathy in dorsal motor nucleus of the vagus (DMV) neurons. Topics discussed include α-Synuclein as an established causal driver of Parkinson's disease, effect of selective induction of α-synucleinopathy in vagal motoneurons of adult mice on vagal output and GI motility, and fluorescence microscopy and cell size analysis.
- Subjects :
- *MOTOR neurons
*DOPAMINERGIC neurons
Subjects
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 7
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Science Advances
- Publication Type :
- Academic Journal
- Accession number :
- 149347528
- Full Text :
- https://doi.org/10.1126/sciadv.abd3994