负压创面治疗联合高压氧治疗糖尿病足的临床疗效.

Objective Explore the clinical efficacy of negative pressure wound therapy combined with hyperbaric oxygen therapy for diabetic foot. Methods From February 2013 to December 2017, the clinical data of 46 patients with diabetic foot were retrospectively analyzed. All patients were divided into control group (24 patients) and combined treatment group (22 patients) according to the treatment method. According to Wagner grade, the wounds of diabetic foot were classified as 3 to 5 grades, a total of 46 feet. The treatment method such as blood glucose control, anti-infection, debridement of wounds and wet-wrap dressings were performed in the control group. The dressing change, skin grafting or amputation was conducted according to the situation of wounds. The negative pressure wound therapy combined with hyperbaric oxygen therapy on the basis of treatment methods of control group were performed in the combined treatment group. The dressing change, skin grafting, vacuum sealing drainage or amputation was conducted according to the wounds. The wound healing, length of hospital stay and amputation after treatment were observed. Results The total effective rate of combined treatment group (59%) was significantly higher than that of the control group (33%). The length of hospital stay were (25.2±16.5) days in the control group and (28.7±12.8) days in the combined treatment group. There were 11 toe amputations in 9 patients in the control group, including 7 cases of thigh amputations and 1 case of calf amputation. There were 8 toe amputations in 5 patients, including 2 cases of calf amputation. Compared with the control group, the amputation rate was significantly decreased (z = -2.617, P<0.05) and the rate of amputation above the ankle was significantly reduced (33% vs 9%, P<0.05). Conclusion The negative pressure wound therapy combined with hyperbaric oxygen therapy for diabetic foot can significantly reduce the amputation rate and improve the quality of life for patients after discharge. [ABSTRACT FROM AUTHOR]