Actinidia eriantha Polysaccharide and PD1-Antibody Combination Therapy Enhances Antitumor Efficacy in Colorectal Cancer–Xenograft Mice.

Conclusion AEPS combined with PD1 can suppresses tumor growth and extend survival of colorectal cancer-xenograft mice by regulating their immunofunction, and this therapy showed better therapeutic efficacy in treating colorectal cancer than single-agent treatments. Conclusion: AEPS and PD1 antibody-combination therapy can suppresses tumor growth and prolong survival of colorectal cancer-xenograft mice by regulating immunofunction, and the combined therapy showed better therapeutic efficacy than the single treatment. These results suggest that AEPS with PD1 combination therapy effectively suppressed tumor growth in colorectal cancer-xenograft mice, and showed better therapeutic efficacy than single treatment with PD1 or AEPS. Powered by TCPDF (www.tcpdf.org) 1 / 1 Figure 5 Combination of AEPS and PD1 antibody stimulated spleen T-cell proliferation and tumor CD8 + T-cell infiltration in colorectal cancer-xenograft mice. [Extracted from the article]