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Regulatory effects of non-steroidal anti-inflammatory drugs on cardiac ion channels Nav1.5 and Kv11.1.

Authors :
Xu, Yijia
Li, Wenwen
Han, Yunuo
Liu, Hongyu
Zhang, Suli
Yan, Jiamin
Sun, Jianfang
Liu, Yanfeng
Zhang, Jinghai
Zhao, Mingyi
Source :
Chemico-Biological Interactions. Apr2021, Vol. 338, pN.PAG-N.PAG. 1p.
Publication Year :
2021

Abstract

Non-steroidal Anti-inflammatory Drugs (NSAIDs) are widely used because of their excellent anti-inflammatory and analgesic effects. However, NSAIDs could cause certain cardiac side effects, such as myocardial infarction, heart failure, atrial fibrillation, arrhythmia and sudden cardiac death. Therefore, meloxicam, nimesulide, piroxicam, and diclofenac were selected and the whole cell patch clamp technique was used to investigate the electrophysiological regulatory effects of them on the sodium channel hNav1.5 and potassium channel hKv11.1, which were closely associated to the biotoxicity of cardiac, and to explore the potential cardiac risk mechanism. The results showed that the four NSAIDs could inhibit the peak currents of hNav1.5 and hKv11.1. Furthermore, the four NSAIDs could affect both the activation and inactivation processes of hNav1.5 with I–V curves left-shifted to hyperpolarized direction in activation phase. These data indicate that the inhibition effects of Nav1.5 and Kv11.1 by meloxicam, nimesulide, piroxicam, and diclofenac might contribute to their potential cardiac risk. These findings provide a basis for the discovery of other potential cardiac risk targets for NSAIDs. [Display omitted] • NSAIDs act as inhibitors of hNav1.5 and hERG. • Nav1.5 and hERG might be involved in the cardiac side effects of NSAIDs. • Diclofenac showed the least inhibition effects on both hNav1.5 and hERG channels. • Minor perturbations of piroxicam and meloxicam lead to major changes in hNav1.5. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00092797
Volume :
338
Database :
Academic Search Index
Journal :
Chemico-Biological Interactions
Publication Type :
Academic Journal
Accession number :
149263918
Full Text :
https://doi.org/10.1016/j.cbi.2021.109425