Antipsychotic drugs: from 'major tranquilizers' to Neuroscience-based-Nomenclature.

The article discusses the introduction of antipsychotic agents in 1950s and their apparent efficacy was shortly followed by a tremendous reduction of institutionalized patients with schizophrenia. It mentions that the established efficacy in treating acute exacerbations of schizophrenia and preventing relapses, and there is also more recent evidence on their efficacy in patients with predominant negative symptoms.