Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation.

Authors :: Falk, Elisa N.
Norman, Kevin J.
Garkun, Yury
Demars, Michael P.
Im, Susanna
Taccheri, Giulia
Short, Jenna
Caro, Keaven
McCraney, Sarah E.
Cho, Christina
Smith, Milo R.
Hung-Mo Lin
Hiroyuki Koike
Bateh, Julia
Maccario, Priscilla
Waltrip, Leah
Janis, Meaghan
Morishita, Hirofumi
Source :: Science Advances. 3/3/2021, Vol. 7 Issue 10, p1-16. 16p.
Publication Year :: 2021
Abstract: The article presents a study that explores the Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation. It identifies that dynamic regulation of the nicotinic cholinergic system as a key driver of attentional circuit maturation associated with top-down frontal neurons projecting to visual cortex.

Subjects :: *NICOTINIC receptors
*22Q11 deletion syndrome
*DENDRITIC spines
*FRAGILE X syndrome
*NICOTINIC acetylcholine receptors

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