Comparison of macular neovascularization lesion size by the use of Spectral‐Domain Optical Coherence Tomography Angiography and Swept‐Source Optical Coherence Tomography Angiography versus Indocyanine Green Angiography.

Purpose: To compare the lesion sizes of macular neovascularization (MNV) imaged with spectral‐domain (SD) and swept‐source (SS) optical coherence tomography angiography (OCTA) as well as indocyanine green angiography (ICGA). Methods: In this prospective, observational case series, patients showing a secured diagnosis of MNV on ICGA or Fluorescein Angiography, were imaged by SD‐OCTA and SS‐OCTA on the same day. Lesion size was measured on 3 × 3‐mm2 and 6 × 6‐mm2 scans using the Maestro 2 SD‐OCTA (Topcon Corporation, Tokyo Japan) and the Triton SS‐OCTA device (Topcon Corporation, Tokyo Japan) and compared to ICGA (Spectralis HRA, Heidelberg, Germany). Results: Twenty eyes from 20 patients (11 females, 55%) were enrolled. The neovascularization area measured on 6 × 6‐mm2 SD‐OCTA was lower compared to that outlined on SS‐OCTA, however, not reaching statistical significance (p = 0.094). Regarding 3 × 3‐mm2 measurements, the median lesion sizes between the two OCTA devices were comparable (p = 0.492). Indocyanine green angiography depicted a larger lesion area than both OCTA devices, however, not reaching statistical significance. Conclusion: SD‐OCTA tends to show smaller areas of MNV extension than SS‐OCTA regarding 6 × 6 mm2 scans. The lesion size of MNV can be very well compared between the different devices, emphasizing the use of OCTA for monitoring neovascular area. Lesion measurements on SS‐OCTA correlate better with ICGA than SD‐OCTA. [ABSTRACT FROM AUTHOR]