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Strategies to Better Target Fungal Squalene Monooxygenase.

Authors :
Sagatova, Alia A.
Source :
Journal of Fungi. Jan2021, Vol. 7 Issue 1, p1-13. 13p.
Publication Year :
2021

Abstract

Fungal pathogens present a challenge in medicine and agriculture. They also harm ecosystems and threaten biodiversity. The allylamine class of antimycotics targets the enzyme squalene monooxygenase. This enzyme occupies a key position in the sterol biosynthesis pathway in eukaryotes, catalyzing the rate-limiting reaction by introducing an oxygen atom to the squalene substrate converting it to 2,3-oxidosqualene. Currently, terbinafine—the most widely used allylamine—is mostly used for treating superficial fungal infections. The ability to better target this enzyme will have significant implications for human health in the treatment of fungal infections. The human orthologue can also be targeted for cholesterol-lowering therapeutics and in cancer therapies. This review will focus on the structural basis for improving the current therapeutics for fungal squalene monooxygenase. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2309608X
Volume :
7
Issue :
1
Database :
Academic Search Index
Journal :
Journal of Fungi
Publication Type :
Academic Journal
Accession number :
149098409
Full Text :
https://doi.org/10.3390/jof7010049