Implementación de un protocolo de anestesia intravenosa durante la validación de un prototipo de respirador en modelo porcino.

Objectives: The results obtained through the application of an intravenous anesthetic protocol are reviewed, in the development of the procedures carried out on two pigs in the framework of an authorized project for the validation of a prototype mechanical ventilator (respirator). All done according to the exceptional protocols enabled during the COVID-19 health crisis. Material and methods: The animals were subjected to an anesthetic procedure, in which, an infusion of propofol was used and in demand additioned fentanyl. Maintenance was achieved by means of continuous pressure-controlled mandatory ventilation, with an approved anesthetic ventilator. The baseline values with anesthetic monitorization and blood gas are compared with those obtained during connection to the respirator prototype under normal conditions, also with the same prototype under conditions of respiratory stress induced with a preparation of 0.9% saline solution wash. Results: The stability of the anesthetic state achieved with the proposed anesthetic protocol is revealed, without identifying significant statistical differences between the monitoring parameters obtained during the three anesthetic periods. Conclusions: This work shows how said intravenous anesthetic protocol allowed the completion of the prototype validation project, maintaining at all times the conditios that led to the authorization of the project. [ABSTRACT FROM AUTHOR]