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Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections.
- Source :
-
Journal of Infectious Diseases . 3/1/2021, Vol. 223 Issue 5, p838-842. 5p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Many influenza studies assume that symptomatic and asymptomatic cases have equivalent antibody responses.<bold>Methods: </bold>This study examines the relationship between influenza symptoms and serological response. Influenza-positive index cases and household members in Managua, Nicaragua, during 2012-2017 were categorized by symptom status.<bold>Results: </bold>Antibody response was assessed using hemagglutination inhibition assays (HAI). Among 510 cases, 74.5% had ≥4-fold increase in HAI antibodies, and 75.3% had febrile illness. In a logistic regression model, febrile cases had 2.17 times higher odds of a ≥4-fold titer rise compared to asymptomatic cases (95% confidence interval, 1.02-4.64).<bold>Conclusions: </bold>Studies relying on serological assays may not generalize to asymptomatic infections. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 223
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 149056235
- Full Text :
- https://doi.org/10.1093/infdis/jiaa426