Memantine attenuated E. coli K1-induced tight junction injuries through inhibition of α7 nAChR-dependent pathway in vitro.

Memantine attenuated E. coli K1-induced tight junction injuries through inhibition of 7 nAChR-dependent pathway in vitro In our study, we aim to determine the effects of MEM on tight junction injury in blood-brain barrier (BBB) induced by E. coli K1 in vitro. B Conclusion: b Our study suggests that MEM enhances the expression of the tight junction- associated proteins (Occludin and ZO-1) and alleviates the tight junction damage through inhibiting 7 nAChR signaling way. [Extracted from the article]