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Modulation of N-terminal methyltransferase 1 by an N6-methyladenosine-based epitranscriptomic mechanism.
- Source :
-
Biochemical & Biophysical Research Communications . Mar2021, Vol. 546, p54-58. 5p. - Publication Year :
- 2021
-
Abstract
- Protein α-N-methylation is an evolutionarily conserved type of post-translational modification; however, little is known about the regulatory mechanisms for this modification. Methylation at the N 6 position of adenosine in mRNAs is dynamic and modulates their stability, splicing, and translational efficiency. Here, we found that the expression of N-terminal methyltransferase 1 (NTMT1) protein is altered by depletion of those genes encoding the reader/writer/eraser proteins of N 6-methyladenosine (m6A). We also observed that MRG15 is N-terminally methylated by NTMT1, and this methylation could also be modulated by reader/writer/eraser proteins of m6A. Together, these results revealed a novel m6A-based epitranscriptomic mechanism in regulating protein N-terminal methylation. Image 1 • Studied for the first time the m6A-mediated epi-transcriptomic regulation of NTMT1. • Revealed that MRG15 is subjected to α-N-methylation. • Demonstrated that α-N-methylation of MRG15 is regulated by the m6A pathway. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 546
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 148982928
- Full Text :
- https://doi.org/10.1016/j.bbrc.2021.01.088