A new Tetrahydrofuran sesquiterpene skeleton from Artemisia sieberi.

A new Tetrahydrofuran sesquiterpene 7,10‐Epoxy‐10‐methy‐dodeca‐1,6(14)‐diene‐3,4‐diol (1) along with three known Tetrahydrofuran sesquiterpene compounds 2,6,10‐trimethyl‐2,5:7,10‐dioxido‐dodeca‐3,11‐dien‐5‐ol (2), cis‐hydroxydavanone (3), and davana acid (4). All isolated metabolites were tested against MCF‐7, HCT‐116, and HepG‐2 cancer cell lines. Compound 2 showed potent activity against MCF‐7 (IC50 = 26 ± 0.4 μg/ml), HCT‐116 (IC50 = 30.4 ± 0.9 μg/ml), and HepG‐2 (IC50 = 20.5 ± 0.3 μg/ml) cancer cells. [ABSTRACT FROM AUTHOR]