Undifferentiated connective tissue disease at risk for systemic sclerosis: Development of a short-term predictive score and a risk stratification tool.

Thirty six patients evolved into definite SSc during the first 3 years from enrollment: 31 fulfilled ACR/EULAR criteria; 5 SSc sine scleroderma criteria i.e. distal esophageal hypomotility as detected by Barium X-Ray. Dear Editor, Undifferentiated Connective Tissue Disease at risk for Systemic Sclerosis (UCTD-risk-SSc), otherwise referred to as very early-early SSc (from VEDOSS: very early and early diagnosis of systemic sclerosis), is a condition characterized by Raynaud's phenomenon (RP) and either SSc serum marker autoantibodies or a capillaroscopic scleroderma pattern or both, but without satisfying classification criteria for SSc nor those for SSc sine scleroderma [1]. References 1 G. Valentini, Undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (so far referred to as very early/early SSc or pre-SSc). [Extracted from the article]