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Aucuparin Suppresses Bleomycin-Induced Pulmonary Fibrosis Via Anti-Inflammatory Activity.

Authors :
Lee, Soo Yeon
Park, Soo-Yeon
Lee, Gyeong-Eun
Kim, Hyunsik
Kwon, Jae-Hwan
Kim, Mi Jeong
Yoon, Ho-Geun
Source :
Journal of Medicinal Food. Feb2021, Vol. 24 Issue 2, p151-160. 10p.
Publication Year :
2021

Abstract

Idiopathic pulmonary fibrosis (IPF) is a lung disease that results in scarring of the lungs for an unknown reason. Although many studies have been conducted on IPF, precise mechanisms and treatments have not yet been identified. In this study, we found that aucuparin, a natural product isolated from Sorbus aucuparia, inhibited pulmonary fibrosis in a bleomycin (BLM)-induced lung fibrosis mouse model. In the lung samples of mice treated with aucuparin, the gene expression of inflammation and macrophage activation markers was reduced compared to those treated with BLM alone. Moreover, aucuparin decreased the expression of profibrotic marker genes and increased the expression of antifibrotic marker genes. Finally, we observed that aucuparin significantly suppressed transforming growth factor-β-induced activation of inflammatory cytokine production and collagen synthesis from macrophages and fibroblasts, respectively. Taken together, these data demonstrate that aucuparin inhibits lung fibrosis via its anti-inflammatory action and support its potential to be a therapeutic drug for IPF treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1096620X
Volume :
24
Issue :
2
Database :
Academic Search Index
Journal :
Journal of Medicinal Food
Publication Type :
Academic Journal
Accession number :
148855595
Full Text :
https://doi.org/10.1089/jmf.2020.4861