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Role of yes‐associated protein in interleukin‐13 induced nasal remodeling of chronic rhinosinusitis with nasal polyps.
- Source :
-
Allergy . Feb2021, Vol. 76 Issue 2, p600-604. 5p. - Publication Year :
- 2021
-
Abstract
- Keywords: CRSwNP; epithelial remodeling; HIPPO; IL-13; YAP EN CRSwNP epithelial remodeling HIPPO IL-13 YAP 600 604 5 02/20/21 20210201 NES 210201 Chronic rhinosinusitis (CRS) is a common otolaryngologic disease. IF results on day 2 (A-D) and day 24 (E-H), showed that IL-13+VP treatment resulted in a decreased basal cell percentage (D, H), decreased YAP activity in basal cells (B, F), and a decreased basal cell proliferation level (C, G). Generally, YAP inhibits epithelial differentiation.8 However, our results demonstrated that YAP can also promote goblet cell differentiation and YAP inhibitor reversed IL-13-induced goblet cell hyperplasia. [Extracted from the article]
- Subjects :
- *NASAL polyps
*INTERLEUKIN-13
*SINUSITIS
Subjects
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 76
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 148800659
- Full Text :
- https://doi.org/10.1111/all.14699