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Synthesis and antiproliferative assessments of new derivatives of isothiazolo[3,4-d]pyrimidine.
- Source :
-
Journal of Sulfur Chemistry . Apr2021, Vol. 42 Issue 2, p193-201. 9p. - Publication Year :
- 2021
-
Abstract
- Various derivatives of 5-aryl-4-imino-3-(phenylamino)-4,5-dihydroisothiazolo[3,4-d]pyrimidines (3a-f) were synthesized. The synthesis has been done through treatment of 3-amino-4-cyano-5-(phenylamino)isothiazole with various aryl isothiocyanates. The isothiazole skeleton was obtained by the reaction of malononitrile and phenyl isothiocyanate followed by chloramine treatment. Some of the synthesized dihydroisothiazolo[3,4-d]pyrimidines were tested against different cancer cell lines, including ACHN, HeLa, HL-60, MCF-7, and PC3. Malignant cells were cultured in RPMI medium and incubated with different concentrations of the mentioned compounds. Cell viability was assessed using the MTS assay. The cytotoxicities of the synthesized compounds are not significant and are probably safe for other biological use. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17415993
- Volume :
- 42
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Sulfur Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 148751963
- Full Text :
- https://doi.org/10.1080/17415993.2020.1841192