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Effects of differential distributed-JUP on the malignancy of gastric cancer.

Authors :
Chen, Yanlin
Yang, Liping
Qin, Yilu
Liu, Shuiqing
Qiao, Yina
Wan, Xueying
Zeng, Huan
Tang, Xiaoli
Liu, Manran
Hou, Yixuan
Source :
Journal of Advanced Research. Feb2021, Vol. 28, p195-208. 14p.
Publication Year :
2021

Abstract

JUP, a homologue of β-catenin, is a cell-cell junction protein involved in adhesion junction and desmosome composition. JUP may have a controversial role in different malignancies dependence of its competence with or collaboration with β-catenin as a transcription factor. In this study, we focused on the role of JUP in tumor progress and metastasis of GC. We investigated whether that the function of JUP is related to its cellular location in GC development process from epithelium-like, low malignant GC to advanced EMT-phenotypic GC. Gradual loss of membrane and/or cytoplasm JUP was closely correlated with GC malignancy and poor prognostics. Knockdown of JUP in epithelium-like GC cells causes EMT and promotes GC cell migration and invasion. Ectopic expression of wild JUP in malignant GC cells led to an attenuated malignant phenotype such as reduced cell invasive potential. In mechanism, loss of membrane and/or cytoplasm JUP abolished the restrain of JUP to EGFR at cell membrane and resulted in increased p-AKT levels and AKT/GSK3β/β-catenin signaling activity. In addition, nuclear JUP interacts with nuclear β-catenin and TCF4 and played a synergistic role with β-catenin in promoting TCF4 transcription and its downstream target MMP7 expression to fuel GC cell invasion. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20901232
Volume :
28
Database :
Academic Search Index
Journal :
Journal of Advanced Research
Publication Type :
Academic Journal
Accession number :
148729963
Full Text :
https://doi.org/10.1016/j.jare.2020.06.026