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DNA Mismatch Repair and its Role in Huntington's Disease.

Authors :
Iyer, Ravi R.
Pluciennik, Anna
Jones, Lesley
Pearson, Christopher E.
Wheeler, Vanessa
Source :
Journal of Huntington's Disease. 2021, Vol. 10 Issue 1, p75-94. 20p.
Publication Year :
2021

Abstract

DNA mismatch repair (MMR) is a highly conserved genome stabilizing pathway that corrects DNA replication errors, limits chromosomal rearrangements, and mediates the cellular response to many types of DNA damage. Counterintuitively, MMR is also involved in the generation of mutations, as evidenced by its role in causing somatic triplet repeat expansion in Huntington's disease (HD) and other neurodegenerative disorders. In this review, we discuss the current state of mechanistic knowledge of MMR and review the roles of key enzymes in this pathway. We also present the evidence for mutagenic function of MMR in CAG repeat expansion and consider mechanistic hypotheses that have been proposed. Understanding the role of MMR in CAG expansion may shed light on potential avenues for therapeutic intervention in HD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18796397
Volume :
10
Issue :
1
Database :
Academic Search Index
Journal :
Journal of Huntington's Disease
Publication Type :
Academic Journal
Accession number :
148596190
Full Text :
https://doi.org/10.3233/JHD-200438